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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
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1996 1
1997 8
1998 4
1999 4
2000 1
2001 5
2002 8
2003 3
2004 3
2005 2
2006 3
2007 2
2008 2
2009 1
2010 1
2011 3
2014 2
2015 4
2016 3
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2019 2
2020 2
2021 2
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67 results

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Page 1
Gene-gene interaction and RNA splicing profiles of MAP2K4 gene in rheumatoid arthritis.
Shchetynsky K, Protsyuk D, Ronninger M, Diaz-Gallo LM, Klareskog L, Padyukov L. Shchetynsky K, et al. Clin Immunol. 2015 May;158(1):19-28. doi: 10.1016/j.clim.2015.02.011. Epub 2015 Feb 27. Clin Immunol. 2015. PMID: 25732927 Free article.
Individuals heterozygous for rs10468473 demonstrated higher expression of total MAP2K4 mRNA in blood, compared to A-allele homozygous. We discovered a novel, putatively translated, "cassette exon" RNA splice form of MAP2K4, differentially expressed in peripheral blo …
Individuals heterozygous for rs10468473 demonstrated higher expression of total MAP2K4 mRNA in blood, compared to A-allele homozygous …
Analysis of Association between MAP2K4 Gene Polymorphism rs3826392 and IL-1b Serum Level in Southern Chinese Han Ischemic Stroke Patients.
Gu L, Wu Y, Hu S, Chen Q, Tan J, Yan Y, Liang B, Tang N. Gu L, et al. J Stroke Cerebrovasc Dis. 2016 May;25(5):1096-1101. doi: 10.1016/j.jstrokecerebrovasdis.2015.12.035. Epub 2016 Feb 5. J Stroke Cerebrovasc Dis. 2016. PMID: 26856463
However, the association between MAP2K4 gene polymorphisms and ischemic stroke (IS) has not yet been published. ...RESULTS: Significant association was not observed between MAP2K4 gene polymorphism rs3826392 and IS susceptibility in all genetic models (P > .05). …
However, the association between MAP2K4 gene polymorphisms and ischemic stroke (IS) has not yet been published. ...RESULTS: Significa …
MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies.
Lu J, Zhou N, Yang P, Deng L, Liu G. Lu J, et al. Med Sci Monit. 2019 Nov 11;25:8499-8508. doi: 10.12659/MSM.916458. Med Sci Monit. 2019. PMID: 31710596 Free PMC article.
Dual luciferase reporter assay showed that mitogen-activated protein kinase 4 (MAP2K4) was a direct target of miR-27a-3p. miR-27a-3p inhibitor significantly promoted the cell viability of KA-induced neurons, inhibited cell apoptosis, promoted the expression of Bcl-2, and d …
Dual luciferase reporter assay showed that mitogen-activated protein kinase 4 (MAP2K4) was a direct target of miR-27a-3p. miR-27a-3p …
Baicalin Protects Against Acute Pancreatitis Involving JNK Signaling Pathway via Regulating miR-15a.
Zhen J, Chen W, Liu Y, Zang X. Zhen J, et al. Am J Chin Med. 2021;49(1):147-161. doi: 10.1142/S0192415X21500087. Epub 2020 Dec 26. Am J Chin Med. 2021. PMID: 33371810
In this study, miR-15a is the core intermediate in baicalin regulation, which increased through baicalin treatment and protected pancreas cells and tissues, inhibiting the JNK signaling pathway by targeting MAP2K4. The long non-coding RNA MALAT1 is also a direct target of …
In this study, miR-15a is the core intermediate in baicalin regulation, which increased through baicalin treatment and protected pancreas ce …
Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways.
Hu WH, Johnson H, Shu HB. Hu WH, et al. J Biol Chem. 1999 Oct 22;274(43):30603-10. doi: 10.1074/jbc.274.43.30603. J Biol Chem. 1999. PMID: 10521444 Free article.
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that interacts with several receptors, including TRAIL-R1, TRAIL-R2, and TRAIL-R4. ...Moreover, inhibition of NF-kappaB by IkappaBalpha sensitizes cells to tumor necrosis …
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that interacts with several recep …
The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity.
Chou AH, Liao CC, Lee HC, Liou JT, Liu FC. Chou AH, et al. Drug Des Devel Ther. 2019 Nov 14;13:3887-3898. doi: 10.2147/DDDT.S215473. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31814709 Free PMC article.
RESULTS: DEX treatment significantly attenuated PILT in mice, with the strongest beneficial effects at a dose of 25 mug/kg. The levels of hepatic cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), in addition to myeloperoxidase (MPO) activity, wer …
RESULTS: DEX treatment significantly attenuated PILT in mice, with the strongest beneficial effects at a dose of 25 mug/kg. The levels of he …
MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4.
Hu G, Zhao X, Wang C, Geng Y, Zhao J, Xu J, Zuo B, Zhao C, Wang C, Zhang X. Hu G, et al. Cell Death Dis. 2017 Oct 26;8(10):e3140. doi: 10.1038/cddis.2017.522. Cell Death Dis. 2017. PMID: 29072705 Free PMC article.
Cartilage dyshomeostasis contributes to osteoarthritis (OA) pathogenesis, and tumor necrosis factor (TNF)-alpha has critical role in this process by driving inflammatory cascades and cartilage degradation. ...
Cartilage dyshomeostasis contributes to osteoarthritis (OA) pathogenesis, and tumor necrosis factor (TNF)-alpha has critical role in …
Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus.
Daigeler A, Chromik AM, Geisler A, Bulut D, Hilgert C, Krieg A, Klein-Hitpass L, Lehnhardt M, Uhl W, Mittelkötter U. Daigeler A, et al. Int J Oncol. 2008 Jun;32(6):1205-20. doi: 10.3892/ijo_32_6_1205. Int J Oncol. 2008. PMID: 18497982
As alternative chemotherapeutics, we tested the antibiotic taurolidine (TRD) on KYSE 270 human esophageal carcinoma cells alone and in combination with rhTRAIL (TNF related apoptosis-inducing ligand). Viability, apoptosis and necrosis were visualized by TUNEL assay and qua …
As alternative chemotherapeutics, we tested the antibiotic taurolidine (TRD) on KYSE 270 human esophageal carcinoma cells alone and in combi …
Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells.
Yoshizumi M, Fujita Y, Izawa Y, Suzaki Y, Kyaw M, Ali N, Tsuchiya K, Kagami S, Yano S, Sone S, Tamaki T. Yoshizumi M, et al. Exp Cell Res. 2004 Jan 1;292(1):1-10. doi: 10.1016/j.yexcr.2003.08.003. Exp Cell Res. 2004. PMID: 14720501
Tumor necrosis factor-alpha (TNF-alpha) stimulates expression of endothelial cell (EC) genes that may promote atherosclerosis in part by an activation of mitogen-activated protein (MAP) kinases. ...
Tumor necrosis factor-alpha (TNF-alpha) stimulates expression of endothelial cell (EC) genes that may promote atherosclerosis in part …
MicroRNA gga-miR-200a-3p modulates immune response via MAPK signaling pathway in chicken afflicted with necrotic enteritis.
Pham TT, Ban J, Hong Y, Lee J, Vu TH, Truong AD, Lillehoj HS, Hong YH. Pham TT, et al. Vet Res. 2020 Feb 3;51(1):8. doi: 10.1186/s13567-020-0736-x. Vet Res. 2020. PMID: 32014061 Free PMC article.
Gga-miR-200a-3p was observed to be a direct transcriptional repressor of ZAK, MAP2K4, and TGFbeta2 that are involved in mitogen-activated protein kinase (MAPK) pathway by targeting the 3'-UTR of their transcripts. ...
Gga-miR-200a-3p was observed to be a direct transcriptional repressor of ZAK, MAP2K4, and TGFbeta2 that are involved in mitogen-activ …
67 results